STEM in PDF
Overview
It is advised not to create math in PDF format. It is possible to create accessible math in PDF, but it's highly complex and is limited to specific assistive technology. It is much easier to convert the PDF to a Word document and reinsert any of the STEM content as MathML.
In some cases, you may receive an accessible PDF with math properly embedded. If the student is comfortable with using NVDA, then keep the math as is.